Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Divisions of Gastroenterology, Hepatology, and Nutrition and of Developmental Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA. Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Janssen Research and Development, Spring House, PA, USA. Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. Division of Gastroenterology and Hepatology, Washington University School of Medicine, St. Louis, MO, USA. Division of Gastroenterology and Hepatology, University of Florida, Gainesville, FL, USA. Division of Gastroenterology and Hepatology, Houston Methodist Hospital, Houston, TX, USA. Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic Foundation, Cleveland, OH, USA. Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.